> For the complete documentation index, see [llms.txt](https://covid19.gitbook.io/guia-coronavirus/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://covid19.gitbook.io/guia-coronavirus/h.-tratamiento/untitled-1.md).

# 103. ¿Se puede usar bromhexina (Bisolvon®)?

La bromhexina (193) es un **mucolítico** que disminuye la tos mediante la **inhibición** selectiva de la proteína transmembrana serina 2 (TMPRSS2), esta **proteína participa en la invasión del epitelio respiratorio por parte de la influenza, el SARS CoV y el MERS**. Parece que la concentración que alcanza a nivel de las células epiteliales bronquiales es 4-6 veces mayor que la concentración en plasma por lo que podría inhibir a la TMPRSS2.

La **bromhexina está siendo estudiada** como tratamiento de **la tos y el dolor torácico** en casos leves de neumonía por COVID-19 en China (ClinicalTrials.gov: NCT04273763). Se hipotetiza si pudiese ser un agente profiláctico para prevenir la infección en pacientes de alto riesgo para SARS CoV- 2

[Aportaciones a la pregunta](https://docs.google.com/forms/d/e/1FAIpQLSd992WLwl69fkmd3QJY8o_sSl5N1gDtMzVv5MukiUn8Q0xeyQ/viewform)

Actualizado: 26/04/20


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